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2 edition of Synthesis of nitrogen containing heterocycles via radical cyclisation found in the catalog.

Synthesis of nitrogen containing heterocycles via radical cyclisation

Robert Paul Filik

Synthesis of nitrogen containing heterocycles via radical cyclisation

by Robert Paul Filik

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  • 6 Currently reading

Published by typescript in [s.l.] .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Warwick, 2000.

StatementRobert Paul Filik.
The Physical Object
Paginationxxiv, 252p.
Number of Pages252
ID Numbers
Open LibraryOL18688117M

The synthesis of novel nitrogen containing heterocycles Arife Yazici University of Wollongong Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong. Research Online is the open access institutional repository for the University of Wollongong. Thieme E-Books & E-Journals Synfacts Category: Synthesis of Heterocycles. Back to Category List. Current Issue 05/ Copper-Catalyzed Aerobic Indole Synthesis through Nitrogen Radical Cyclization Full Text HTML PDF ( kb) Oxidative Cross-Coupling of Nonactivated Substrates to Yield 1-Benzazepines.

Buy Asymmetric Synthesis of Nitrogen Heterocycles on FREE SHIPPING on qualified orders Asymmetric Synthesis of Nitrogen Heterocycles: Jacques Royer, H. P. Husson: : Books.   On the other hand, iminyl radical has been well-established as intermediates for the construction of N-containing 5- and 6-membered heterocycles including indoles and pyridi17,18,19,20,Cited by: 6.

Heterocycles 1 are one of the major classes of organic compounds. They are cyclic compounds containing one or more heteroatom (oxygen, nitrogen, sulphur etc.). These compounds are of biological and industrial importance. Many materials that are essential to life include a heterocyclic moiety;. This volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural : Hardcover.


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Synthesis of nitrogen containing heterocycles via radical cyclisation by Robert Paul Filik Download PDF EPUB FB2

Herein, we demonstrate I 2 /TBHP promoted, solvent controlled, regio- and chemoselective 5-exo-trig or 6-endo-trig radical cyclization of electronically unbiased 1,n-enynes to synthesize nitrogen-containing heterocycles.

These metal-free protocols confer access to synthetically robust piperidine motif-bearing iodinated-homoallylic alcohol and pyrrolidine fused cyclopropane : Mohana Reddy Mutra, Ganesh Kumar Dhandabani, Jing Li, Jeh-Jeng Wang.

Synthesis of nitrogen-containing heterocycles with isocyanides, isothiocyanates, nitriles, imines, oxime derivatives, and other related compounds has been deeply investigated in organic synthesis. This chapter mainly focuses on summarizing radical cyclization reactions of these C-N unsaturated precursors to afford N -heterocycles in the past decade as well as some earlier feature Cited by: 2.

Synthesis of Nitrogen-Containing Heterocycles via Imidoyl or Iminyl Radical Intermediates. , DOI: /__9. Cheng Jin, Lianzheng Su, Daxi Ma, Mingrong Cheng.

Transition-metal-free, visible-light-mediated cyclization of o -azidoarylalkynes with aryl diazonium by: Filik, Robert Paul () Synthesis of nitrogen containing heterocycles via radical cyclisation. PhD thesis, University of : Robert Paul Filik.

The effect of positional change of the carbonyl group of enamides on Bu 3 SnH-mediated alkyl radical cyclization leading to five- six- seven- and eight-membered nitrogen-containing heterocycles was by: generated underwent cyclization in the 5-endo sense, to ultimately afford the substituted indazoles (86a-f).

There was also some evidence for cyclization to the other azo nitrogen (closure in the 4-exo sense) to form a 4-membered ring. The aryl radical also underwent hydrogen atom abstraction from tributyltin hydride in competition with : Cheryl P.

Kunka. The combination of Ugi reaction and xanthate radical cyclization onto alkenes allows an easy access to various highly functionalized heterocycles. The addition of chloroacetic acid to primary amines, aldehydes and isocyanides in methanol followed by the treatment with potassium ethyl xanthate.

The Synthesis of Novel Nitrogen Containing Heterocycles A thesis submitted in (partial) fulfillment of the requirements for the award of the degree DOCTOR OF PHILOSOPHY From UNIVERSITY OF WOLLONGONG By Arife YAZICI, Org.

Chem. (Hons., ) Supervisor: Prof. Stephen G. Pyne School of Chemistry January   Acyl radicals, key intermediates in the radical carbonylation, have both nucleophilic and electrophilic characters, depending on the attacking reagents and the electrophilic nature is particularly useful to achieve synthesis of nitrogen-containing heterocycles by the reactions with imines, amines, azides, and by: 1.

Synthesis of Eight- Nine- and Ten-Membered, Nitrogen-Containing Quinone-Fused Heterocycles Sarit Yerushalmi, N. Gabriel Lemcoff*, Shmuel Bittner* Department of Chemistry, Ben Gurion University of the Negev, Beer Sheva,IsraelAuthor: Sarit Yerushalmi, N.

Gabriel Lemcoff, Shmuel Bittner. Nitrogen Containing Heterocycles 9Higher-Membered Ring Systems - Saturated 6-membered systems – piperidines, dihydropyridines N O CH 3 OEt Meperidine (piperidine) relieves pain, narcotic analgesic N H Cl H 3 C CHOCH 2 CH 2 NH 2 MeOOC COOEt Amlodipine (dihydropyridine) Ca2+ channel blocker, Antihypertensive, antianginal HN N H O O.

Rh‐Catalyzed Synthesis of Nitrogen‐Containing Heterocycles. A large number of transition metal‐catalyzed C H activation reactions for the synthesis of N‐heterocycles have been developed. In particular, the formation of indoles, pyrroles, pyrrolidines, indolizines, quaternary ammonium salts, isoquinolones, and lactam derivatives Author: Krishnamoorthy Muralirajan, Chien‐Hong Cheng.

Trichloroacetamides can act as radical precursors to synthesize nitrogen-containing heterocycles in a variety of processes, mainly involving atom transfer radical cyclizations (ATRC), mediated by Cu(I) or Ru(II) catalysts, and the hydride reductive method, employing either Bu 3 SnH or (Me 3 Si) 3 SiH, or recently NaBH 3 by: 8.

Heterocycle synthesis via radical reactions* Takeaki Naito Medicinal Chemistry Laboratory, Kobe Pharmaceutical UniversityMotoyamakita, Higashinada, KobeJapan Abstract: A novel synthetic method for the preparation of nitrogen-containing heterocycles. Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive molecules.

We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime : Jia-Lin Tu, Jia-Li Liu, Wan Tang, Ma Su, Feng Liu.

Synthesis of nitrogen containing heterocycles via radical cyclisation Author: Filik, Robert Paul ISNI: Awarding Body: University of Warwick Current Institution: University of Warwick Date of Award: Availability of Full Text: Author: Robert Paul Filik. Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom Benhur Godoi, Ricardo F.

Schumacher, and Gilson Zeni * Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, CCNE, UFSM, Santa Maria-Rio Grande do Sul, Brazil Cited by: The unique features of the isocyano group make isocyanides particularly useful for the synthesis of a number of important classes of nitrogen heterocycles, such as pyrroles, indoles, and quinolines.

Several cocyclizations of isocyanides via zwitterions and radical intermediates as well as transition‐metal‐catalyzed syntheses Cited by: A palladium-catalyzed cyclization reaction for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles couples two of the carbons of a propargyl unit with various diamine components to provide products in very good yields with high regio- and stereochemical control.

Nitrogen heterocycles are part of peptides and alkaloids. Both can of course also occur in the respective hybrid natural products. Sulphur-containing heterocycles are present in few polyketides and more widespread in peptidic natural products of both, Cited by:.

Organoselenium-Catalyzed Synthesis of Oxygen- and Nitrogen-Containing Heterocycles Ruizhi Guo, Jiachen Huang, Haiyan Huang and Xiaodan Zhao* *Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, GuangzhouP.

R. China, Email: zhaoxd3 Stork et al. have reported a facile synthesis of a β-C-glucoside via stereoselective radical cyclisation using a phenyl 1-seleno-β-d-glucose derivative having a phenylethynylsilyl group as a radical acceptor, tethered at the 6-hydroxyl.

Recently, Shuto et al. have developed an efficient method for preparing β-C-glucosides via radical cyclisation with a silicon tether based on the conformational Cited by: Impressive functional group tolerance has been demonstrated, including aryl halides, ethers and heterocycles.

This elegant process sets the stage for the design of a plethora of dearomatizing cyclizations for the synthesis of nitrogen heterocycles via aminoketyl radicals [38,39].Cited by: 4.